Baptiste Santamaria (born 9 March 1995) is a French professional footballer who plays as a midfielder for Bundesliga club SC Freiburg.
Santamaria is a youth exponent from Tours FC. He made his Ligue 2 debut on 18 October 2013 against CA Bastia replacing Bryan Bergougnoux after 88 minutes in a 1–2 away win at the Stade Armand Cesari.
On 25 June 2016, Santamaria joined Ligue 1 side Angers SCO after a transfer fee offer of €400,000 from Angers to Tours had previously been rejected by the latter.
In September 2020, Santamaria moved to Bundesliga club SC Freiburg after protracted negotiations with Angers. German sports magazine kicker reported the transfer fee as “about €10 million”, the highest is SC Freiburg’s history.