Vasco Regini (born 9 September 1990) is an Italian professional footballer who plays as a left-back for Sampdoria.
Regini made his Serie A debut for Sampdoria on 9 May 2009 in a game against Reggina. He was successively acquired on loan by Lega Pro Prima Divisione club Foggia later in August 2010.
On 31 January 2020, he joined Parma on loan.
Regini was a member of Italy U-20 team from 2008 to 2011. In 2011–12 season he played twice for Italy under-21 Serie B representative team plus another unofficial charity match against Italy U20. All three match Regini was the captain.