Paolo Ghiglione (born 2 February 1997) is an Italian professional footballer who plays as winger for Serie A club Genoa.
Born in 1997, Ghiglione started his football career with Derthona, playing for their youth teams until 2007. In August 2007, he had moved to A.C. Milan Primavera and he was loaned to A.C. Pavia for six months from January to June 2012. In August 2012, he finally transferred to Genoa C.F.C. Primavera.
In 2015, Ghiglione was called up to the Genoa first team. He had ridden the pine in the several games from 2015 to 2016, but he did not play any games for the first team.
On 1 July 2016, SPAL announced that Ghiglione was loaned to SPAL until the end of 2016/17 Season. On 5 November 2016, he made professional league debut against Novara at Stadio Silvio Piola in the Serie B, playing the game as a starter during 71 minutes.