Gonzalo Escalante (born 27 March 1993) is an Argentine professional footballer who plays as a midfielder for Italian club Lazio.
Born in Bella Vista, Buenos Aires, Escalante finished his formation with Boca Juniors. He made his professional debut on 13 April 2013, coming on as a half-time substitute for Clemente Rodríguez in a 1–6 away loss against San Martín de San Juan for the Primera División championship.
On 28 August 2014, Escalante was loaned to Italian Serie B side Calcio Catania, in a season-long deal with a buyout clause. He scored his first professional goal on 28 October, netting the first in a 5–1 home routing of Virtus Entella.
On 29 January 2015, Escalante was bought outright by the Sicilians. He appeared in 26 matches and scored one goal during the campaign, as his side finished only 16th.
On 16 July 2015, Escalante moved to La Liga side SD Eibar on loan for one year. He made his debut in the category on 24 August, starting and scoring the second in a 3–1 away win against Granada CF.
On 11 January 2016, Escalante joined the Armeros permanently, signing a contract until 2020.
On 13 January 2020, Escalante reached an agreement with Lazio to join the club ahead of the 2020–21 season, penning a four-year contract.